【摘要】 采用6 甲氧基 2 乙酰萘与浓盐酸在缚酸剂三乙胺存在的条件下进行水解反应制得6 羟基 2 乙酰萘。同时通过正交设计研究了反应的优化条件,即 6 甲氧基 2 乙酰萘、浓盐酸、三乙胺与二氯甲烷的比例为:1 g∶90 ml∶0.75 ml∶2.5 ml,反应收率为 79%。反应监控为TLC(展开剂为:正庚烷、二氯甲烷和丙酮=3∶6∶2.5,v/v)。盐酸的用量大幅度降低,产品成本降低36%。更多还原

【Abstract】 hydroxy-2-acetonaphthene was obtained by the hydrolysis of 6-methoxy- 2-acetonaphthene in the presence of HCl （36%） and triethylamine as a catalyst. The optimum conditions were studied by orthogonal design. The ratio of 6-methoxy-2-acetonaphthene/ conc.HCl/Et₃N/CH₂Cl₂ was 1∶90∶0.75∶2.5（g∶v∶v∶v）, and the yield was 79%. The reaction was monitored by TLC, and the developed solution.was n-heptane:CH₂Cl₂:acetone （3∶6∶2.5, v/v）. The consumption of HCl was reduced greatly and the cost was dropped by 36%.更多还原