【摘要】 目的　探讨 5 AZA CdR重新激活MDA MB 2 3 1乳腺癌细胞雌激素受体基因的表达。方法　采用免疫组织化学的方法 ,对用浓度为 2mg/L的 5 AZA CdR处理MDA MB 2 3 1乳腺癌细胞前后和阳性对照MCF 7乳腺癌细胞雌激素受体基因的表达情况进行检测分析。结果　 5 AZA CdR处理过的MDA MB 2 3 1乳腺癌细胞ER的阳性表达率明显增高 (P <0 .0 5 )。结论　 5 AZA CdR可以重新激活MDA MB 2 3 1乳腺癌细胞雌激素受体基因的表达更多还原

【Abstract】 Objective To evaluate the expression of estrogen receptor (ER ) on MDA-MB-231 breast cancer cells reactivated by 5-aza-2’-deoxycytidine (5-AZA-CdR).Methods The expression of ER on MDA-MB-231 breast cancer cells reactivated by 5-AZA-CdR was tested by immuneohistochemistry.Results The positive rate of ER on MDA-MB-231 breast cancer cells treated by 5-AZA-CdR was higher than that of pretreatment (P<0.05).Conclusions 5-AZA-CdR can reactivate the expression of ER on MDA-MB-231 breast cancer cells.更多还原