【摘要】 为阐明TDI在小鼠睾丸及附睾中的代谢过程,对TDI进行体外代谢研究.应用HPLC测定TDI在小鼠睾丸及附睾中的线性范围、回收率及代谢常数.TDI在小鼠睾丸及附睾中的代谢均附合一级动力学方程,平均回收率大于96%.TDI在小鼠睾丸及附睾中代谢为有毒性的产物,为TDI的生殖毒性提供了依据.更多还原

【Abstract】 To elucidate the metabolism of mouse testis and epididymis,this paper studies TDI in vivo and main metabolite of mouse testis and epididymisadded TDI by HPLC.After incubated(1.5 h),the total recovery of TDI was 96%.The metabolism of mouse testis and epididymis was toxic,which give the evidences to the toxicity effects of TDI on the reproductive systems.更多还原