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多形核白细胞显微图像分析

Analysis of Microscopic Images of Multi-shape-nucleus Leukocyte

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【作者】 王玥玥王秋光张敬冬

【Author】 WANG Yue-yue , WANG Qiu-guang, ZHANG Jing-dong ( Electrical & Electronic Engineering College, Harbin Univ. Sci. Tech. , Harbin 150040, China; Harbin Disease Precaution Center, Harbin 150080, China)

【机构】 哈尔滨理工大学电气与电子工程学院哈尔滨疾病预防控制中心 黑龙江哈尔滨150040黑龙江哈尔滨150040黑龙江哈尔滨150080

【摘要】 为改变目前淋病病原体诊断存在的检验周期长,误诊率高的落后状况,将图像处理技 术用于淋病病原体中多形核白细胞显微图像的分析.在对其进行了二维OTSU分割的基础上,通 过4-邻域标识方法标记多形核白细胞区域,给出了自动测量细胞的面积、周长及形状因子等几何 参数的有效方法.实验结果表明,得到的几何参数反映了多形核白细胞的形状特征,这为深入研究 淋病病原体显微图像中淋球菌的分布创造了条件.该方法同样适用于其他类似传染病的显微镜分 析处理.

【Abstract】 At present, the diagnosis of gonorrhea pathogen is time-consuming with a high error ratio. In order to overcome these shortcomings, this paper applies the technique of image processing to the measurement and analysis of the microscopic image of multi-shape-nucleus leukocyte. We propose a method, which first segments the image using the Two-Dimensional OTSU thresholding method, then identifies the multi-shape-nucleus region by the 4-neighbors mark method, finally actualizes the auto-measurement of multi-shape-nucleus leukocyte’ s parameters such as dimension, perimeter, shape factor and so on. Experiments show that the determined parameters can well present the shape feature of the multi-shape-nucleus, which provides the prerequisite for further researching the distributing of the pathogen of gonorrhea; it also turns out to be suitable for microscopic image analysis of other similar epidemic.

  • 【文献出处】 哈尔滨理工大学学报 ,Journal of Harbin University of Science and Technology , 编辑部邮箱 ,2005年05期
  • 【分类号】TP399
  • 【下载频次】86
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