【摘要】 目的研究周平均最低气温与急性冠心病发病的关系。方法采用时间序列的Poisson广义相加模型(generalizedadditivemodel,GAM),在控制了长期趋势、季节趋势和其他混杂因素后,研究周平均气温与周急性冠心病发病数的关系,并按年龄、性别、既往病史和发病28d内是否存活等进行分层分析。结果当周平均气温低于6℃时,急性冠心病发病率开始高于基线发病率,并随着气温的降低而升高。在分层分析中,周平均最低气温对不同人群急性冠心病发病的影响是类似的,差别仅在于危险气温范围和相对危险度的大小上。结论低温可以诱发急性冠心病发生,男性、65岁及以上人群及既往有冠心病史者是受低温影响的高危人群。更多还原

【Abstract】 Objective To observe the relationship between temperature and the incidence of acute coronary heart disease. Methods After controlling long time trend season and other confounding factors the relationship between temperature and incidence rate of acute coronary heart disease was explored by using generalized additive models GAMs and the relationship between temperature and acute coronary heart disease specified by age gender disease history was also explored. Results The incidence of acute coronary heart disease began to be higher than the baseline as weekly average temperature was lower than 6 ℃ and it increased with the weekly average temperature decreasing. The relationship between weekly average temperature and the incidence of acute coronary heart disease was found similar among different population groups but relative risk and dangerous temperature range were different. Conclusion Low temperature cold easily induces the acute coronary heart disease in males aged over 65 years or with history of acute coronary heart disease.更多还原