【摘要】 以邻氨基苯甲酸为起始原料, 经重氮化、芳基化、取代和脱水等步骤合成药物中间体4′甲基2 腈基联苯。通过正交实验得到芳基化反应较佳条件为: 10 mol/L氢氧化钠15 mL, 甲苯30 mL, 反应温度5℃, 反应时间5 h, 产物4′甲基2 联苯羧酸的产率为59 4%。考察了脱水剂种类, 脱水反应较佳的实验条件为氯化亚砜15 mL, 4′甲基2 联苯酰胺2 6 g, 反应8 h, 产物4′甲基2 腈基联苯的产率为67 7%。更多还原

【Abstract】 Aminobenzoic acid was used to synthesize 4′methyl2cyanobiphenyl, which was one of medicine intermediates ,by diazotization, acylation, substitution, and dehydration. The reaction conditions of 15mL of 10N sodium hydroxide, 30mL of toluene, reacting for 5h at 5℃ , could give 59 4% 4′methyl2biphenyl carboxylic acid. The quantity and kind of the dehydrating catalyst were studied. By adding 15mL of thionyl chloride, 2 6gram of 4methyl2′bipheny amide, reacting for 8h, the yield of 4′methyl2cyanobiphenyl could reach 67 7%.更多还原