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血浆凝血酶原时间测定对肝硬化的临床价值
Clinical value of serum PT in patients with cirrhosis
【摘要】 目的探讨肝硬化患者血浆凝血酶原时间与肝硬化病变程度及血清肝纤维化指标的相关性。方法测定肝硬化患者血浆凝血酶原时间及血清肝纤维化指标,并按Ch ild-pugh方法将肝功能分为A、B、C三级。结果随着临床肝硬化程度的加重,血清肝纤维化指标逐渐增高,凝血酶原时间则逐渐延长。肝硬化患者PT值与HPC III、IV-C、LN及HA呈正相关(P<0.001或0.005),PT与IV-C及HA之间的相关性随着肝硬化病情加重而更加明显(P<0.001)。结论肝硬化时血浆凝血酶原时间与肝纤维化有一定相关性。联合检测血清HPC III、IV-C、LN、HA及凝血酶原时间对估测肝硬化的严重程度及预后有十分重要的临床价值。
【Abstract】 Objective To study the relationship among serum PT,liver fibrosis marks and Child-pugh in patients with cirrhosis.Methods The serum PT,bilirubin,prothrombin time,HA,HPCIII,IV-C and LN in 72patients with cirrhosis were measured.Results The serum HPCIII,IV-C,LN,HA and PT increased gradually with the degree of clinical liver cirrhosis deteriorated.Serum PT is positively correlated to HPCIII、IV-C、LN and HA(P<0.001or 0.005).Conclusion There were close relationship between serum PT and serum marks of liver fibrosis.Measuring the concentration of serum PT,HA,HPCIII,IV-C and LN simultaneously has utilizable and reliable clinical value in predicting the degrees and prognosis of liver cirrhosis.
【Key words】 Cirrhosis; PT; Marks of liver fibrosis; Child-pugh grade;
- 【文献出处】 邯郸医学高等专科学校学报 ,Journal of Handan Medical College , 编辑部邮箱 ,2005年05期
- 【分类号】R575.2
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