【摘要】 目的:应用超声心动图评价扩张型心肌病患者升主动脉弹性及年龄、血压对升主动脉弹性的影响。方法:我们对19例扩张型心肌病患者和18例正常对照者进行超声心动图检查。升主动脉弹性用Ep和β表示。结果:扩张型心肌病患者升主动脉Ep(1.31±0.69N/m2×106)和β(18.71±8.74)显著高于正常人(0.30±0.12N/m2×106,P<0.001;4.62±1.65,P<0.001)。扩张型心肌病组和正常组中男女性之间升主动脉弹性无显著差异。正常组中,年龄分别与Ep(r=0.66,P=0.003)和β(r=0.65,P=0.003)分别相关,收缩压仅与Ep(r=0.63,P=0.005)相关;扩张型心肌病组中,年龄与Ep(r=0.72,P=0.001)和β(r=0.71,P=0.001)分别相关,收缩压仅与Ep(r=0.56,P=0.01)相关。结论:扩张型心肌病患者升主动脉弹性减低。年龄、收缩压为影响升主动脉弹性的重要因素。更多还原

【Abstract】 Objective: To assess the ascending aortic distensibility in patients with idiopathic dilated cardiomyopathy and the effects of aging and blood pressure on ascending aortic distensibility by transthoracic echocardiography. Method: 19 patients with idiopathic dilated cardiomyopathy and 18 healthy subjects underwent assessment of the ascending aortic distensibility by echocardiography. Ascending aortic distensibility was shown by aortic pressure-strain elastic modulus(Ep) and stiffness index beta(β). Results: Ep(1.31±0.69 N/m 2×10 6) and β(18.71±8.74) were significantly higher in patients with idiopahtic dilated cardiomyopathy than in healthy subjects(0.30±0.12 N/ m 2×10 6, P <0.001; 4.62±1.65, P <0.001 respectively). There were no differences in distensibility between men and women in either patients with idiopathic dilated cardiomyopathy or healthy subjects. Among healthy subjects, age was positively correlated with Ep(r=0.66, P=0.003) and β(r=0.65, P=0.003) respectively and systolic blood pressure was only positively correlated with Ep(r=0.63, P=0.005). Among patients with idiopahtic dilated cardiomyopathy, age was positively correlated with Ep(r=0.72, P=0.001) and β(r=0.71, P=0.001) respectively and systolic blood pressure was only positively correlated with Ep(r=0.56, P=0.01). Conclusions: This study demonstrated that decreased ascending aortic distensibility exists in patients with idiopathic dilated cardiomyopathy. Aging and systolic blood pressure are important factors affecting the ascending aortic distensibility.更多还原