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超声波和Zn/蒙脱石-ZnCl₂使芳香醛片呐醇化

Pinacolization of aromtic aldehydes using Zn/montmorillonite-ZnCl₂ and ultrasound

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【Author】 LIU Qing-fu~1,ZHAI Jian-hua~2,PANG Guo-xun~3 (1. Department of Chemistry,Xingtai College, Xingtai Hebei 054001, China;2. Foreign Affairs Office,Hebei University of Science and Technology,Shijiazhuang Hebei 050018,China;3.Medicament office,The People’s Hospital of Hebei,Shijiazhuang Hebei 050071,China)

【机构】邢台学院化学系；河北科技大学国际交流与合作处；河北省人民医院药剂室河北邢台054001；河北石家庄050018；河北石家庄050071；

【摘要】用超声波照射Ｚｎ/蒙脱石ＺｎＣｌ₂和含50%（质量分数）ＴＨＦ的一些芳香醛水溶液2～3ｈ,芳香醛发生偶联反应,生成片呐醇,产率为23%～87%。2,4 二氯苯甲醛、β 苯基丙烯醛发生偶联反应时,片呐醇产率分别达到87.1%和74.8%;对甲基苯甲醛、糠醛发生偶联反应时,化学选择性较好;Ｚｎ/蒙脱石ＺｎＣｌ₂重复使用3次,活性无显著降低。更多还原

【Abstract】 The coupling reaction aromtic aldehydes leading to pinacols were carried out by using Zn/montmorillonite-ZnCl₂ in 50% aqueous THF under ultrasound with 23%⁸7% yield.2,4-dichiorophenyl and β-benzaldehyde were coupled with 87.1% and 74.8% yields respectively.When occurs the reaction of pinacols p-methylbenzaldehyde and 2-furaldehyde , the chemistry selectivity is better; Zn/ montmorillonite-ZnCl₂ is repeatedly used for 3 times, with no active notable reduction. Contrasting experiment in progress goes deep into the study of this reaction . Its structure was characterized by IR, ¹H NMR and MS.The advantages of this method lie in moderate condition,high chemical selectivity,high yield and the reusability of the catalyst.更多还原