【摘要】 目的观察对十二指肠溃疡(DU)急性穿孔〔不宜行胃大部切除术或高选择性迷走神经切除术(HSV)〕的病例行穿孔修补术后,采用口服奥美拉唑、阿莫西林和甲硝唑三联疗法的治疗效果。方法治疗组38例,术后以口服奥美拉唑6周、阿莫西林和甲硝唑各2周三联疗法治疗;对照组31例,术后以单服奥美拉唑6周治疗。疗程结束后胃镜复查溃疡翕合率和复发率。结果复查溃疡愈合率,治疗组为94.7%(36/38),对照组为61.3%(19/31);复查溃疡复发率:治疗组为8.3%(3/36),对照组为73.7%(13/19)。结论对DU穿孔不宜行彻底性手术的患者,采用穿孔单纯修补术后,口服奥美拉唑、阿莫西林和甲硝唑的三联疗法,取得较为满意的疗效。更多还原

【Abstract】 OBJECTIVE To observe the therapeutic effect that triple-therapy with omeprazole,amoxicillin and metronidazol used after repairing of perforation for the patientes with acute perforated duodenal ulcer(DU)who were not suitable for subtotal gastrectory)or patients with highly selective vagotomy (HSV).METHODS In treated group 38 patients took omeprazole for 6 weeks,and took amoxicillin and metronidazol separately for 2 weeks after operation;in control group 31 patients only took omeprazole for 6 weeks.To check the ulcer healing effect by gastroscope after treatment.RESULTS Healing rate:treated group is 94.7%(36/38),control group 61.3%(19/31);and recurrent rate:treated group is 8.3%(3/36),control group 73.7%(19/31).CONCLUSION After simple repair of perforation triple-therapy with omeprazole,amoxicillin and metronidazol used for the patients with DU who do not fit for radical operation,the effect is satisfactory.更多还原