【摘要】 目的探讨血浆B型利钠肽(BNP)水平在慢性心力衰竭(CHF)中的诊断价值,以及血浆BNP与CHF严重程度和左心室功能的关系。方法对127例临床诊断为CHF的患者,就诊后24h内取静脉血测定血浆BNP,并行超声心动图检查,分析血浆BNP与NYHA心功能分级及左心室射血分数之间的关系。结果按照心功能分级,Ⅰ～Ⅳ级患者血浆BNP逐步增加,有显著相关性P<0.01;左心室舒张末期内径≤60mm的血浆BNP显著低于内径>60mm者,P<0.01;且左心室射血分数≤0.50者血浆BNP显著大于射血分数>0.50者P<0.001。结论血浆BNP水平提示能客观的反映心功能的情况,对临床CHF的诊断及危险分层有重要意义。更多还原

【Abstract】 Objective Plasma B-Type natriuretic peptide (BNP) was conducted asses the clinical value in the diagnosis of congestive heart failure and the relationship between BNP and ventriculai dysfunction. Methods We enrolled 127 patients with CHF. Plasma levels of B-Type natriuretic peptides (BNP) were measured and in these patients. Results The mean BNP concentration in blood samples obtained from patients with CHF was high gradually with the degree of NYHA from Ⅰ to Ⅳ. P<0.01. The BNP level in patients with low left ventricular ejection fraction (LVEF) ≤ 0.05 were higher than in that with LVEF>0.05, (P<0.01). The BNP level in patients with high left ventricular end-diastolic diameter (LVEDD) ≥60mm was higher than in that with low LVEDD<60mm, P<0.01. Conclusions BNP plasma level is a good marker to left ventricular function.更多还原