【摘要】 目的探讨影响维持性血液透析(MHD)患者血浆氧化应激水平的因素。方法选取维持性血液透析患者69例,取透析前血浆测定丙二醛(MDA)和晚期蛋白氧化产物(AOPP)水平。调查患者原发病、心血管并发症及是否应用血管紧张素转换酶抑制剂(ACEI)治疗。结果维持性血液透析患者的MDA和AOPP水平较正常人明显升高(p<0.001)。有心血管并发症者较无心血管并发症者升高(p<0.05)。应用ACEI治疗的患者(11例)比不用ACEI患者的MDA和AOPP降低(4.05±0.74vs5.42±1.88,P<0.05;87.53±40.20vs128.00±59.83,P<0.05)。结论维持性血液透析患者血浆氧化应激水平较正常人明显升高,有心血管并发症者升高更明显。应用ACEI治疗可能降低维持性血液透析患者氧化应激的水平。更多还原

【Abstract】 Objective To explore the factors that influence the oxidation stress of maintaining hemodislysis(MHD)patients.Methods Malondialhehyde(MDA)and AOPP were detected in69patients.The data including primary kidney diseases and cardiovascular diseases of the patients and whether they took angiotensin converting enzyme inhibitors(ACELI)in the past three months were reviewed.Results The level of MDA and AOPP in MHD patients are higher than those in controls(P<0.001).The patients with cardiovascular diseases have higher levels of MDA and AOPP than those without cardiovascular diseases(P<0.001).The levels of MDA and AOPP in MHD patients taking ACEIs are lower than those in patients not taking ACEIs(4.05±0.74vs5.42±1.88,P<0.05;87.53±40.20vs128.00±59.83,P<0.05).Conclusion s Oxidation stress in MHD patients is higher than that in controls.ACEIs may alleviate the oxidation stress of MHD patients.更多还原