【摘要】 目的通过观察新生儿黄疸的脑干听觉诱发电位(BAEP)的变化来指导高压氧治疗及预测预后,以期确立BAEP为预测预后及指导应用高压氧防治胆红素脑病的客观指标。方法对65例伴脑干听觉诱发电位异常的新生儿高胆红素血症患儿随机分成两组,治疗组35例,对照组30例,两组均采用相同的综合治疗,治疗组给予高压氧治疗,10次为一疗程,一个疗程分两组同期检查BAEP,3个月后再复查BAEP。结果治疗前治疗组与对照组统计学分析BAEP各波的潜伏期,峰间期异常情况无差异,第一次复查期BAEP异常两组有显著性差异,治疗第二疗程3个月复查,高压氧治疗组BAEP均恢复正常,对照组则仍有3例BAEP异常。结论BAEP可作为胆红素脑病早期的预测及指导高压氧治疗的观察指标。更多还原

【Abstract】 Objective To investigate the value of brain stem auditory evoked potentials(BAEP)for infant on forecasting the protective effects of hyperbaric oxygen(HBO)therapy on bilirubin-encephalopathy at the early stage.Methods 65patients with neonatal jaundice and abnormal BAEP were divided randomly into two groups:the treated group with hyperbaric oxygen therapy(group A,n=35);the control group without hyper-baric oxygen therapy(group B,n=30);the patients of two groups both accepted the same combination treat-ment.In the treated group HBO treatment was performed once a day,10sessions constituting a single thera-peutic course.After the first therapeutic course,BAEP were reviewed.If the result of BAEP was abnormal,the hyperbaric oxygen treatment would be continued.Three months later,BAEP would be reviewed again.Results before treatment,a statistical comparison between group A and B was not significant with regard to the abnor-mal situation on the latent period and interval peak latency of BAEP(p>0.05).After the first therapeutic course there are significant differences with regard to the abnormal rate of BAEP.Between the two groups(p<0.01).After three months,the results of BAEP in treated group were normal,but there were3cases with ab-normal BAEP in the control group.Conclusions BAEP can act as an authentic objective index to forecasting the outlook for the patients with bilirubin-encephalopathy.And it may be taken as a guide in hyperbaric oxy-gen therapy on bilirubin-encephalopathy at the early stage.更多还原