【摘要】 目的探讨TA(泰素加阿霉素)化疗方案在局部晚期乳腺癌(T3N1M0除外)综合治疗中临床价值。方法用TA方案对28例局部晚期病人进行新辅助化疗2个疗程。结果28例中,完全缓解(CR)4例(14.3%),部分缓解(PR)22例(78.5%),无效(NC)1例(3.6%),进展(PD)1例(3.6%),总有效率92.8%。主要不良反应为消化道症状28例,脱发28例,心脏毒性2例,过敏反应11例,骨髓抑制4例,发热6例,头晕3例,肝功能异常1例。结论TA方案在局部晚期乳腺癌新辅助化疗中有较好疗效,临床应用毒性反应可耐受。更多还原

【Abstract】 Objective To investigate the clinical value of TA (combined Taxol and ADM) chemotherapy in the associated treatment of local advanced breast cancer. Methods 28 patients with local advanced breast cancer were treated by two courses of Taxol and ADM as neoadjuvant chemotherapy. Results There were 22 cases of CR (14.3%),22 cases of PR(78.5%),one case of NC (3.6% and only one case of PD(3.6%), the total effective rate of 92.8%.Main side affects included digestive symptoms in 28 cases,hair loss in 28 cases,cardiotoxicity in 2 cases,hypersensitiviness in 11 cases,inhibition of bone marrow in 4 cases,fever in 6 cases,dizziness in 3 cases and liver function damage in 1 cases. Conclusion Taxol and ADM has a good effect in local advanced breast cancer as neoadjuvant chemotherapy.The clinical toxicity can be tolerated.更多还原