【摘要】 目的:观察中药二至丸对老年痴呆(alzhe im er d isease AD)模型小鼠脑组织Na+-K+-ATPase、Ca2+-ATPase活性及学习记忆的影响。方法:颈背部皮下注射D-半乳糖建立亚急性老年痴呆模型,测定脑组织中Na+-K+-ATPase、Ca2+-ATPase活性、采用跳台法测定小鼠的学习记忆能力。结果:中药二至丸能明显提高Na+-K+-ATPase、Ca2+-ATPase活性、缩短小鼠学习潜伏期,延长记忆潜伏期、减少错误次数。结论:中药二至丸能改善老年痴呆模型小鼠的学习记忆能力,提高ATP酶的活性,维持脑组织的正常功能。更多还原

【Abstract】 Objective: To observe the effects of Erzhiwan on the Na⁺-K⁺-ATPase,Ca²⁺-ATP ase activities and learning memory in mice model of Alzheimer Disease.Methods: The mice were performed by neck back hypodermic injection of D-galactose to set up the subacute Alzheimer Disease model,tested for learning memory by the method of diving platform,and determined for the Na⁺-K⁺-ATPase & Ca²⁺-ATPase activity in their brain tissues.Results: Erzhiwan could obviously shorten the latency of learning period,prolong the incubation period of memory and reduce the times of mistakas.Conclusion: Erzhiwan can improve the learning memory of Alzheimer Disease mice,raise activation of ATPase and maintain the normal function of the brain tissues.更多还原