【摘要】 目的通过本研究了解在骨肉瘤患者中区域淋巴结转移的发病率、淋巴结肿大原因及与预后的关系。方法对1963年至2004年受治的946例骨肉瘤病人进行临床回顾,对76例行术前淋巴结活检的患者进行病理回顾。结果病理证实有4例患者出现了淋巴结转移,这些患者初诊时未发现有其他血行转移。所有淋巴结转移的患者均于术后两年内死亡。绝大多数淋巴结增大者病理学表现为窦增生。结论骨肉瘤患者中淋巴结转移少见,如出现转移则预后极差,预后与出现血行转移者一样。淋巴结有免疫作用,淋巴结肿大多为非特异性反应。目的通过本研究了解在骨肉瘤患者中区域淋巴结转移的发病率、淋巴结肿大原因及与预后的关系。方法对1963年至2004年受治的946例骨肉瘤病人进行临床回顾,对76例行术前淋巴结活检的患者进行病理回顾。结果病理证实有4例患者出现了淋巴结转移,这些患者初诊时未发现有其他血行转移。所有淋巴结转移的患者均于术后两年内死亡。绝大多数淋巴结增大者病理学表现为窦增生。结论骨肉瘤患者中淋巴结转移少见,如出现转移则预后极差,预后与出现血行转移者一样。淋巴结有免疫作用,淋巴结肿大多为非特异性反应。更多还原

【Abstract】 Objective To determine the incidence of lymphatic metastasis and function of lymph nodes and the prognosis of patients with lymphatic metastasis in osteosarcoma patients. Methods 946 osteosarcoma treated during 1963 to 2004 were reviewed and 76 cases with lymph nodes biopy were studied histologically. Results 4 patients who had no lung metastasis at presenting had lymphatic metastasis and all these 4 patients died of disease within two years. Enlarged lymph nodes revealed non-specific sinus hyperplasia. Conclusions Lymphatic metastasis in osteosarcoma is rare and has the same poor prognosis of lung metastasis. Regional lymph nodes have anti-cancer immune function and should be preserved before being proved malignancy.更多还原