【摘要】 目的 :探讨老年 2型糖尿病、高血压病、冠心病患者及其子女在胰岛素代谢上的改变 ,以了解高胰岛素在上述疾病发病上的作用及高胰岛素这一易患因素的遗传性。方法 :随机选择老年 2型糖尿病、高血压病及冠心病病人各 38、32、34例 ,并从每例病人的一级子女中随机选择一位子女组成子代组 ,同法选择 34例健康老年人及其一级子代组成对照组。每一样本分别空腹检测身高、体重、空腹与餐后 2 h血糖 ,空腹胰岛素 (FINS) ,并计算体重指数 (BMI)。结果 :糖尿病、高血压病病人及其子代存在高胰岛素现象 ,而且糖尿病病人的子女存在血糖增高、体重增加的趋势。结论 :高胰岛素血症可能是糖尿病、高血压病的共同发病基础 ,并具有遗传倾向 ;而单纯冠心病的发病可能与高胰岛素血症的关系并非密切。更多还原

【Abstract】 Objective:To study the change in insulin about the first-degree relatives of the age patients with type-2 diabetes mellitus and primary hypertension and CHD.Methods:Every case selected from age patients and their first-degree relatives have been measured for FPG,PPG,FINS, and based on their body height and weight to calculate their BMI.Results:Hyperinsulinemia exist in the age patients with type-2 diabetes mellitus and primary hypertension. FPG and PPG were significantly higher in first-degree relatives of age patients with type-2 DM than in first-degree relatives of age patients with and primary hypertension and CHD(P<0.001 or 0.05).Conclusion:Hyperinsulinemia maybe is an important factor in type-2 DM and primary hypertension, and their first-degree relatives are easy to disturbed with it. But so do the patients without CHD.更多还原