【摘要】 为探讨THP-COP方案在治疗老年病人NHL中是否优于CHOP方案,142例患者随机接受减量的CHOP方案治疗和THP-COP方案治疗,这些方案基本上每隔三周重复一次,共3个疗程以上。结果表明,142例中有68例接受CHOP方案治疗,肿瘤消失(CR)30例占44.1%,肿瘤缩小大于50%(PR)23例占33.8%,总有效率77.9%。74例接受THP-COP方案治疗,CR 35例占47.3%;PR 26例占35.1%,总有效率82.4%;两组比较无统计学差异(P>0.05)。但远期疗效,THP-COP方案优于CHOP方案,且毒副反应前者明显低于后者。可见THP-COP方案因有较高的CR率和(CR+PR)率,对治疗老年病人NHL是非常有用的。更多还原

【Abstract】 To investigate whether THP-COP regimen is more adventage than CHOP regimens in elderly patients with non-Hodgkin’s lymphoma(NHL),these patients were randomly allocated to reduced CHOP regimen and THP-COP regimen.The regimens were basically repeated with three courses of every 3 weeks.the results showed that in 142 cases,68 cases were allocated CHOP regimen,30 in CR,23 in PR,total response rate of 77.9%.74 cases were allocated to THP-COP regimen,35 in CR,26 in PR,total response rate of 82.4%.There was no significant difference between A and B in CR+PR(77.9% vs 82.4%)(P>0.05).But indistance response THP-COP regimen is better than CHOP regimen,in adverse effect THP-COP regimen is less than CHOP regimen.It concluded THP-COP regimen was useful for elderly patients with NHL because of relatively high CR% and(CR+PR)%.更多还原