【摘要】 骨组织微环境中,成骨/基质细胞表达的骨保护素(osteoprotegerin,OPG)和骨保护素配体(osteoprotegerin ligand,OPGL)是调节骨代谢的重要因子。研究表明,成骨/基质细胞的OPG/OPGL相对表达水平与破骨细胞的分化、成熟及骨吸收直接相关。各种刺激骨吸收的生物、物理因素均通过调节成骨/基质细胞的OPG/OPGL相对表达活性,影响破骨细胞的分化和成熟。更多还原

【Abstract】 The expression level of osteoprotegerinOPG and osteoprotegerin ligand(OPGL) by osteoblasts stromal cells in local microenvironment is the key to the differentiation of osteoclasts. Various biological and physical agents stimulating bone resorption affect differentiation of osteoclasts by regulating the expression level of OPG/OPGL. Osteoblasts and stromal cells play crucial roles in osteoclast differentiation and maturation.更多还原