【摘要】 将近红外漫反射光谱技术应用到血糖无创监测中。实验使用Nexus 870傅里叶红外光谱仪及其光纤附件采集了6名不同年龄健康志愿受试者大拇指指尖的近红外漫反射光谱。对光谱进行了平滑、基线校正和一次求导预处理,采用偏最小二乘(PLS)方法在含有葡萄糖吸收峰的75 0 0～85 0 0cm- 1 波段建立同一个体、相同年龄段的不同个体以及不同年龄段的不同个体的校正模型。采集漫反射光谱的同时抽适量的血样在75 2型紫外光栅分光光度计上标定血糖的实际值,并对校正模型计算值和实际标定值进行了比较,结果表明个体建模的相关性很好,相关系数达到0 90 4 71以上,均方差小于0 171。更多还原

【Abstract】 The noninvasive measurement of human blood glucose was achieved with NIR diffusi on reflectance spectrum method. The thumb fingertip NIR diffusion reflectance sp ectra of six different age healthy volunteers were collected using Nexus-870 a nd its NIR fiber port smart accessory. The test was implemented with changin g th e blood glucose concentration for the limosis and satiation of every volunte er. The calibration model was set up using PLS method with the smoothing, baseline c orrection and first derivatives pretreatment spectrum in the 7 500-8 500 cm -1 region for single volunteer, the same age combination and that of different age. When the spectrum was obtained, the actual blood glucose value of every sp ectrum sample was demarcated using ultraviolet spectrophotometer. The correlatio n between the calibration value and true value for single volunteer is better th an that for the combination of volunteers, the correlative coefficients are all over 0.904 71, RMSECs are all less than 0.171.更多还原