【摘要】 目的　研究慢性乙型肝炎患者外周血γ 干扰素 (IFN γ)受体的水平变化及临床意义。方法　收集 5 3例乙型肝炎病毒 (HBV)感染后不同转归者外周血 ,采用流式细胞术检测外周血中CD3+ ,CD4 + ,CD8+ ,自然杀伤细胞 (NK细胞 )和IFN γ受体水平 ,并以 4 0例正常体检者为对照。结果　HBV感染后患者外周血CD3+ ,CD4 + ,CD8+ 淋巴细胞和NK细胞水平均显著下降 (P <0 .0 5 ) ,其中以血清丙氨酸转移酶 (ALT)异常的患者降低最为明显 ,ALT异常者IFN γ受体水平显著低于ALT正常者与正常对照者。结论　IFN γ受体水平可能与乙型肝炎患者的慢性化有关。更多还原

【Abstract】 Objective To study the clinical value of blood IFN -γ receptor level in patients with chronic hepatitis B. Methods Blood samples were collected from 53 patients with chronic hepatitis B, flow cytometry assay was used to detect the levels of CD3 +, CD4 + and CD8 + T lymphocytes, NK cell and IFN-γ receptor. Forty healthy persons were chosen as normal control. Results The levels of CD3 +, CD4 + and CD8 + T lymphocytes and NK cell decreased markedly in patients with chronic hepatitis B, especially in patients with abnormal alanine transaminase (ALT). IFN-γ receptor level in patients with abnormal ALT was significantly lower than that in patients with normal ALT and normal control group. Conclusion The level of IFN-γ receptor may be related with the chronic progress of hepatitis B.更多还原