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用于肺部给药的壳聚糖空心微球的制备
Preparation of porous chitosan particles for pulmonary drug delivery
【摘要】 采用壳聚糖为壁材、烷基多糖苷为赋形剂通过喷雾干燥的方法成功制备出了可用于肺部给药的空心载药微球,其粒径在10μm左右。采用扫描电子纤维镜观察了所得粒子的形貌,并分析了喷雾干燥条件下得到这种薄壁空心结构的原理。
【Abstract】 In this paper, large hollow particle that can be used in pulmonary drug delivery were prepared with spraying drying method in which chitosan was employed as shell matereial, alkyl polyglycosides was utilized as excipient. The particle size of the product was about 10μm. The shape of the particles was observed with scanning electrical microscope (SEM), and the formation mechanism of the thin-shell hollow structure via spaying drying method was analyzed.
【关键词】 喷雾干燥；
肺部给药；
壳聚糖；
烷基多糖苷；
大粒径中空颗粒；
【Key words】 spray drying； pulmonary drug delivery； chitosan(CS)； alkyl polysaccharide glycoside(APG)； large porous particles(LPPs)；
【Key words】 spray drying； pulmonary drug delivery； chitosan(CS)； alkyl polysaccharide glycoside(APG)； large porous particles(LPPs)；
【基金】 国家基金创新群体资助项目(20221603);中国科学院多相反应重点实验室基金资助项目(60104)
- 【文献出处】 功能材料 ,Journal of Functional Materials , 编辑部邮箱 ,2005年04期
- 【分类号】TQ460.1
- 【被引频次】29
- 【下载频次】489