【摘要】 目的:比较柳氮磺胺吡啶(SA SP)、云南白药联合保留灌肠和SA SP、云南白药口服治疗轻、中型溃疡性结肠炎的临床疗效与不良反应。方法:于6年内连续收集经电子肠镜确诊的溃疡性结肠炎患者97例。A组48例予SA SP 2g、云南白药2g加入100m l生理盐水中,保留灌肠,每晚1次;B组49例口服SA SP 4g/d、云南白药2.25g/d。30d后均改为口服SA SP 2g/d,总疗程均为90d。结果:A组总有效率85.4%(41/48),临床治愈率37.5%(18/48);B组总有效率67.3%(33/49),临床治愈率14.3%(7/49),P<0.01,差异有非常显著性。A组中1例因不良反应停药,不良反应发生率6.3%(3/48);B组中5例因不良反应未完成疗程,不良反应发生率22.4%(11/49),两组比较P<0.01,差异有非常显著性。结论:SA SP、云南白药联合保留灌肠治疗轻、中型溃疡性结肠炎疗效好,尤以左半结肠甚,不良反应少。更多还原

【Abstract】 Objective: To compare the efficacy of sulfasalazine(SASP) plus yunnanbaiyao as a retension enema and oral in the light and medium-sized ulcerative colitis patients.Methods: 97 examples patients with ulcerative colitis were final diagnosis through electron enteroscope collected in 6 years.48 examples of group A were administered by retension enema with SASP 2g plus yunnanbaiyao 2g and physiology brine 100ml,1 time per night;The 49 examples of group B took orally SASP 4gd and Yunnanbaiyao 2.25gd,after the 30 days all changes for take orally the 2gd SASP,the total course was all for 90 days.Results: A group total efficacy was 85.4%(4148 example),clinical cure rate was 37.5%(1848);The group B total efficacy rate was 67.3%(3349),clinical cure rate was 14.3%(749),P<0.01,the difference was marked.In A group 1 example because of dys-response stopped the medicine,dys-response rate 6.3%(348);In B group 5 examples did not finish the course because of dys-response,the rate of dys-response was 22.4%(1149),the difference of A and B was significant,P<0.01.Conclusion:The methods of SASP plus yunnanbaiyao as a retension enema is effective for light and medium-sized ulcerative colitis,particularly for the left colon,the dys-response is little.更多还原