【摘要】 目的:探讨早期使用辛伐他汀治疗急性冠脉综合征(ACS)对患者体内炎症因子水平的影响及其作用机制。方法:选取50例ACS患者为研究对象,随机分成辛伐他汀组和常规组(每组25例);辛伐他汀组每晚服辛伐他汀20m g,常规组服安慰剂。随访3周,分析比较辛伐他汀治疗前后血清白细胞介素-6(IL-6)、高敏C反应蛋白(hs-CRP)及血脂水平变化。结果:辛伐他汀组IL-6、hs-CRP、总胆固醇(TC)及低密度脂蛋白胆固醇(LDL-C)浓度明显下降(P<0.001),对照组各项指标无明显变化;相关分析显示,辛伐他汀组血清白细胞介素-6、高敏C反应蛋白下降与血脂下降无关。结论:辛伐他汀具有独立于降脂的抗炎作用,其抗炎作用在急性冠脉综合征患者早期治疗中可能具有重要意义。更多还原

【Abstract】 Objective: To explore the effect of early intervention with simvastatin on serum levels of inflammatory factors in patients with acute coronary syndrome(ACS) and the mechanism by which statin treats ACS.Methods: 50 patients with ACS were included and were randomly assigned to the simvastatin group(n=25) and the routine group(n=25) in this study.The simvastatin group was given simvastatin 20mg per day and the routine group took placebo.Making a three-week follow-up,and the changes of IL-6,hs-CRP and serum lipids levels between groups before and after intervention with simvastatin were compared.Results:After three-week treatment with simvastation,serum IL-6,hs-CRP and total cholesterol(TC) and low density lipoprotein cholesterol(LDL-C) levels were decreased significantly in the simvastatin group(P<0.001),but no significant changes were observed in the routine group.No relationship was found between the rate of decrease of serum IL-6 or hs-CRP and serum lipids levels.Conclusion: Simvastatin possess anti-inflammatory effect which independent of its lipid-lowering action,and the anti-inflammatory effect of simvastatin may play an important role in the early treatment of ACS.更多还原