【摘要】 目的:研究翼状胬肉组织中Bcl-2和细胞间粘附分子–1(ICAM-1)的表达,以及Bcl-2和ICAM-1表达间的关系。方法:应用免疫组织化学法检测30例翼状胬肉组织中Bcl-2和ICAM-1的表达,并与正常结膜组织进行比较。结果:翼状胬肉组织中Bcl-2和ICAM-1的表达均明显高于正常结膜组织(χ2=5.92和χ2=6.65,P<0.01);翼状胬肉的临床分型与Bcl-2和ICAM-1的阳性表达有关﹙P<0.05﹚;翼状胬肉组织中Bcl-2和ICAM-1阳性表达间存在非常显著正相关﹙r=0.628,P<0.01﹚。结论:翼状胬肉组织中Bcl-2和ICAM-1的表达增加,在翼状胬肉的发生和发展中可能通过调控细胞增殖和细胞凋亡起着重要的作用。更多还原

【Abstract】 ATM: To study the expression and the relationship of Bcl-2 and intercellular adhesion molecule-1 (ICAM-1) in pterygium.· METHODS: The expression of Bcl-2 and ICAM-1 were detected in 30 cases with pterygium by immunohistochemical method and were compared with the normal conjunctiva epithelium in other 10 cases.· RESULTS: The expression of Bcl-2 and ICAM-1 was significantly higher in pterygium than in normal conjunctiva epithelium (P <0.01). The expression of Bcl-2 and ICAM-1 did correlate with the clinical type in pterygium. The expression of Bcl-2 was significantly related to that of ICAM-1.· CONCLUSION: The increase of Bcl-2 and ICAM-1 are presented in pterygium, which may contribute to the progression through cell proliferation and apoptosis.·更多还原