【摘要】 目的探讨整合素连接激酶(integrin-linked kinase,ILK)和基质金属蛋白酶(matrix metalloproteinase-9,MMP-9)在非小细胞肺癌(non-small cell lung cancer,NSCLC)中的表达及其与临床病理特征的关系。方法应用SP免疫组织化学方法检测74例手术切除NSCLC标本和10例正常肺组织中ILK和MMP-9蛋白的表达。结果在NSCLC组织中ILK和MMP-9蛋白的阳性表达率分别为74.5%(55/74)和71.6%(53/74),均明显高于正常肺组织(P<0.05)。ILK阳性表达率与原发灶大小,组织学类型,分化程度,淋巴结转移,临床分期均无密切关系(P>0.05);MMP-9阳性表达率与原发灶大小,组织学类型,分化程度,淋巴结转移,临床分期均有密切关系(P<0.05)。结论ILK和MMP-9蛋白过度表达可能分别在NSCLC的发生和发展过程中起重要作用。更多还原

【Abstract】 Objective To investigate the expressions of ILK and MMP-9 and their clinical significance in NSCLC. Methods ILK and MMP-9 expressions in 74 paraffin-embedded specimens of NSCLC and 10 corresponding non-cancer tissues were detected by immunohistochemical staining. The relationship between ILK and MMP-9 expressions and the clinicopathological characteritics were analyzed by Chi-square test. Results The positive expression rates of ILK(74.5%) and MMP-9(71.6%) in NSCLC were both significantly higher than those in normal lung tissues(P<0.05). The positiveexpression rate of ILK was not correlated to histological classification, differerentiation, lymph node metastasis, or TNM stage (P>0.05), while the positive expression of MMP-9 was correlated to histological classification, differerentiation, size of primary tumour, lymph node metastasis, and TNM stage(P<0.05). Conclusion The overexpression of ILK and MMP-9 genes may play an important role in the oncogenesis and development of NSCLC respectively.更多还原