【摘要】 目的:探讨乙肝疫苗接种后的经济效益,为制定和完善乙型肝炎预防免疫策略以及中长期防治规划提供依据。方法:采用成本效益分析、成本效益平衡点分析等药物经济学评价方法。结果:直接计算接种疫苗减少乙型肝炎发病人数产生的净效益NB1为7814629.74元,效益成本比BCR1为13.22;以预期年发病率计算接种产生的净效益NB2为5480509.14元,效益成本比BCR2为9.57;其成本效益平衡点乙型肝炎的发病率为16.48/10万。结论:开展乙肝疫苗免疫接种具有明显和稳定的经济效益,是预防HBV感染,降低乙型肝炎发病率最高效安全的途径。更多还原

【Abstract】 Objective:To study the economic benefits of hepatitis B（HB） vaccination and to lay a foundation for formulation an immunization strategy and to provide inference for middle-long term prvention plan for HB.Methods:Cost-benefit analysis and balance point of Cost-benefit analysis, et al. of pharmacoeconomics was used to study the economic benefits of hepatitis B vaccination. Results:With the direct calculation,the net benefit（NB₁） of decrease incidence cases of HB caused by HB vaccination was 7 814 629.74 yuan, the benefit-cost ration （BCR₁） of HB vaccine was 13.22;with the expectancy annual incidence rate calculation ,the net benefit（NB₂）of decrease incidence cases of HB caused by HB vaccination was 5 480 509.14 yuan, the benefit-cost ration （BCR₂）of HB vaccine was 9.57;The balance point of Cost-benefit of incidence rate of Hepatitis B was 16.48/10 5. Conclusion:It indicated that obvious and steady economic benefits has been gained since mass HB vaccination strategy was used. HB vaccine immunization is the most economic and safe way to prevent the infection of HBV and to decrease the incidence rate of Hepatitis B.更多还原