【摘要】 以顺丁烯二酸酐改性聚乳酸(MPLA)和强碱性乙二胺为原料,通过MPLA中酸酐键与乙二胺中伯胺基间的N-酰化反应将乙二胺共价引入到MPLA中,制得乙二胺改性聚乳酸(EMPLA),企图以强碱性乙二胺克服聚乳酸及其降解产物的酸性。本文详细介绍了EMPLA的制备和纯化方法,并利用茚三酮反应、FT-IR、1H-NMR、13C-NMR和DSC对MPLA和EMPLA进行了全面的比较、表征,结果表明,按文中所述之制备技术能成功地将乙二胺共价引入到MPLA中,为进一步测定EMPLA的生物降解性和细胞相容性等性能并最终应用于医学领域奠定了技术基础和物质基础。更多还原

【Abstract】 Hydrophobicity and increased acidity due to degradation are two fatal shortcomings for poly（lactic acid） （PLA） to be used in biomedical areas. Many chemical modifications have been done to improve its hydrophilicity, but the increased acidity is still a problem. Although introduction of basic salts into PLA by physical blending is a technique to control the pH in local environment of PLA, it could not essentially address the problem of increased acidity. Here we synthesized ethylenediamine modified poly（DL-lactic acid） （EMPLA） by the N-acylation of anhydrides in MPLA （maleic anhydride modified poly（DL-lactic acid）） with ethylenediamine, whereby basic ethylenediamine could neutralize the acidic degrading products of PLA. In this paper, the synthesis and purification of EMPLA were reported in detail, and ninhydrin reaction, DSC, FT-IR, （）¹³C-NMR and （）¹H-NMR were used to characterize EMPLA. The obtained results show that ethylenediamine could be covalently introduced into MPLA by the developed synthetic method, which provides technical and material supports for further detecting biodegradability and biocompatibility of EMPLA and finally applications in biomedical areas.更多还原