【摘要】 目的 :探讨血管内皮细胞生长因子 (VEGF) ,基质金属蛋白酶 2、9(MMP- 2、MMP- 9)在乳腺良性病变及乳腺癌组织中的表达及其对侵袭和转移的影响。方法 :应用免疫组化 SP法检测 10例乳腺良性病变及 2 9例乳腺癌组织中VEGF、MMP- 2和 MMP- 9的表达。结果 :乳腺癌组织中 VEGF、MMP- 2和 MMP- 9的阳性表达率分别为 79.3 (2 3/ 2 9) ,96 .6 (2 8/ 2 9)和 89.7 (2 6 / 2 9) ,与乳腺良性病变组织中 VEGF、MMP- 2、MMP- 9的阳性表达率分别为 30 .0 (3/ 10 ) ,4 0 .0 (4/ 10 )和 30 .0 (3/ 10 )相比较 ,二者的差异有显著的统计学意义 (P<0 .0 1)。VEGF、MMP- 2和 MMP- 9的表达与乳腺癌淋巴结转移呈中度正相关。乳腺癌组织中 VEGF与 MMP- 2、MMP- 9的表达呈中度正相关 ,MMP- 2与 MMP- 9的表达也呈中度正相关。结论 :VEGF、MMP- 2及 MMP- 9的高表达与乳腺癌的浸润和转移密切相关 ,有可能成为判断乳腺癌侵袭和转移的有价值的指标。更多还原

【Abstract】 Objective:To study the expression of VEGF,MMP-2 and MMP-9 in benign and malignant lesions of breast and their effects on the tumor invasiveness and metastasis. Methods:VEGF, MMP-2 and MMP-9 expression was detected by SP method in 10 benign breast lesions and 29 breast carcinomas. Results:The expression rates of VEGF,MMP-2 and MMP-9 were remarkably higher in breast carcinoma than those in benign lesion (79.3% vs 30.0%, 96.6% vs 40.0% and 89.7% vs 30.0%, respectively; P<0.01). There was a positive correlation between VEGF, MMP-2 and MMP-9 expression and nodal metastasis (P<0.05). The expression of VEGF was significantly correlated with that of MMP-2 and MMP-9 (P<0.05), and sodid between MMP-2 and MMP-9 expression (P<0.01). Conclusion:VEGF, MMP-2 and MMP-9 overexpression is strongly related to the invasiveness and metastasis of breast carcinoma, which might be valuable in evaluating tumor invasion and metastasis.更多还原