【摘要】 目的 :研究高脂血症对大鼠急性胰腺炎发生的影响 ,即高脂血症是否是急性胰腺炎的高危因素。方法 :在中剂量Cerulein造成一定比例的急性胰腺炎发病率的基础上 ,通过研究高脂血症对急性胰腺炎发病率的影响来确定高脂血症是否是急性胰腺炎的高危因素。Wistar雄性大鼠随机分为 :①Bal组 ,均衡饲料饲养 2w ;②NS组 ,均衡饲料饲养 2w ,手术日腹腔注射生理盐水 0 .5ml/kg ,每小时 1次 ,共 4次 ;③M组 ,均衡饲料饲养 2w ,手术日腹腔注射Cerulein 10 μg/kg(0 .5ml/kg) ,每小时 1次 ,共 4次 ;④H组 ,高脂饲料饲养 2w ;⑤H +NS组 ,高脂饲料饲养 2w ,手术日腹腔注射生理盐水 0 .5ml/kg ,每小时 1次 ,共 4次 ;⑥H +M组 ,高脂饲料饲养 2w ,手术日腹腔注射Cerulein 10 μg/kg(0 .5ml/kg) ,每小时 1次 ,共 4次。剖腹主动脉采血检测血清淀粉酶、血甘油三脂 ,并取胰腺组织做胰腺病理切片观察。结果 :高脂血症增加急性胰腺炎的发病率 ,H +M组与M组有明显差异 (P <0 .0 5 )。结论 :较正常稍高的高脂血症并不能单独诱发急性胰腺炎 ,但是增加Cerulein诱发的急性胰腺炎的发病率 ,证明高脂血症是急性胰腺炎的高危因素。更多还原

【Abstract】 Objective:To study the influence of hyperlipemia on the acute pancreatitis,and to find whether hyperlipemia is a high risk agent of acute pancreatitis or not.Methods:On the basis of small dosage cerulein resulting in definite proportion morbidity of acute pancreatitis,whether hyperlipemia was a high risk agent of acute pancreatitis was studied through researching the influence of hyperlipemia on the morbility of acute pancreatitis. Wistar male rats were divided into six groups:①Group Bal:balance feed for two weeks.②Group NS:balance feed for two weeks and saline 0.5 ml·kg -1 ·h -1 given through abdominal cavity on operating day for four times.③Group M:balance feed for two weeks and cerulein 10 μg·kg -1 ·h -1 (0.5 ml·kg -1 ·h -1 ) given through abdominal cavity on operating day for four times.④Group H:high fat feed for two weeks.⑤Group H+NS:high fat feed for two weeks and Saline 0.5 ml·kg -1 ·h -1 given through abdominal cavity on operating day for four times.⑥Group H+M:high fat feed for two weeks and cerulein 10 μg·kg -1 ·h -1 (0.5 ml·kg -1 ·h -1 ) given through abdominal cavity on operating day for four times. The serum amylase and serum TG from blood samples and pathological sections of pancreas through laparotomy were tested. The pathological sections were also researched at the same time.Results:Hyperlipemia increased the morbility of acute pancreatitis. And there was obvious difference between group H+M and group M(P<0.05).Conclusion:A little higher hyperlipemia existence doesn’t induce acute pancreatitis,but it can increase the sick rate of cerulein pancreatitis. This study demonstrates that hyperlipemia is a high risk agent of acute pancreatitis.更多还原