【摘要】 目的探讨辛伐他汀的4种给药方式对骨缺损愈合的影响。方法在40只SD大鼠胫骨上建立3mm的骨缺损模型,左侧缺损部位不作处理设为空白对照组、右侧分别给予单纯骨粉修复(A组)、单纯骨粉修复加局部注射辛伐他汀(B组)、局部骨粉复合2.5%辛伐他汀(C组)和骨粉复合15.0%辛伐他汀(D组)修复。术后第4周、8周分别处死各组大鼠,观察骨缺损区成骨情况。结果C组局部愈合正常,无破溃及组织反应,缺损处骨量和骨密度增加明显(比A组高32%,P<0.05),镜下成骨细胞多,纤维组织最少,整体愈合效果最佳;而B组和D组局部都有破溃及类排斥反应性奶酪状分泌物,缺损局部骨量及骨密度与A组相比没有明显增加(P>0.05),炎性细胞及纤维组织较多,个别大鼠局部发生骨折。A组骨密度较空白组高,未见局部有破溃和组织反应,缺损侧胫骨未见完全骨折。而空白组缺损未完全骨性愈合,局部皮肤无破溃及类排除反应,部分大鼠局部发生骨折。结论骨粉复合一定浓度的辛伐他汀对正常大鼠的胫骨缺损愈合有促进作用。更多还原

【Abstract】 Objective To analyse the effect of simvastation on defect repairing of tibia in rats. Methods Bone defects in length model of tibia in forty rats was established. All of the defects of left tibia were filled with nothing as control. The defects of right tibia were separately filled with Bio-oss only (group A), Bio-oss combined with injection of simvastatin on defect (group B), Bio-oss compounded with 2.5% simvastatin (group C), Bio-oss compounded with 15% simvastatin (group D). The rats were sacrificed in 4 and 8 weeks and the bone formation was observed in defect. Results Compared with group B and D, the repairing of defect of group C was better in bone volume and bone density and more osteoblast and less fibre tissue were found. Conclusion Simvastatin combined with bioactive material can improve healing of bone defect.更多还原