【摘要】 合成了水溶性很好的5,3′,5′-三磺酸基-2,3,4,4′-四羟基脱氧安息香三钠盐(TTDB),采用IR、UV、1HNMR和元素分析对其结构进行了表征,并利用X射线单晶衍射仪测定了该化合物的晶体结构.使用荧光光谱法检测了化合物对羟基自由基的清除作用.用循环伏安法探讨了化合物的电化学性质.实验结果表明,5,3′,5′-三磺酸基-2,3,4,4′-四羟基脱氧安息香三钠盐[C14H17Na3O18S3]属于单斜晶系,空间群C2/c,a=1·4223(4)nm,b=2·4327(8)nm,c=1·3596(4)nm,α=90°,β=113·044(5)°,γ=90°,Z=8,V=4·329(2)nm3,Dc=1·925Mg/m3,F(000)=2568,Mr=627·43,R1=0·0950,wR2=0·2648.TTDB的抗羟基自由基的氧化作用优于其相应的脱氧安息香THDB,前者清除羟基自由基的半数有效浓度(EC50)为47·3μmol/L,而后者的EC50则为53·1μmol/L.电化学研究结果表明,THDB和TTDB的氧化还原过程有所差异,前者负扫时在-1·016和-1·228V处出现两个还原峰,正扫时在0·219V处出现一个氧化峰,但后者负扫时仅在-0·999V出现一个还原峰,正扫时在0·193V出现一个氧化峰.更多还原

【Abstract】 A new water soluble compound trisodium 5,3′,5′-trisulfonate-2,3,4,4′-tetrahydroxy-deoxybenzoin（TTDB） was synthesized and characterized by IR, UV, ¹H NMR, and elemental analysis. Single crystals of（TTDB） was determined by X-ray single crystal diffraction. The scavenging effect of compounds on hydroxy radicals was detected by fluorescent spectrophotometry. The electrochemistry behavior of the compounds in non-aqueous solution DMF was carried out by means of cyclic voltammetry. The experimental result shows that the crystal [C₁4H₁7Na₃O₁8S₃] belongs to monoclinic space group C2/c with unit cell constants a={1.422 3（4） nm,} b=2.432 7（8） nm, c=1.359 6（4） nm, β=113.044（5）°, Z=8, V=4.329（2） nm³, D_c =1.925 Mg/m³, F（000）=2 568, M-r=638.43, R₁=0.095 0, wR₂=0.264 8. The half effective concentration EC₅0 of scanvenging hydroxy radicals of compounds THDB and TTDB are 53.1 and 47.3 μmol/L, respectively. The electrochemistry redox processes of THDB and TTDB are different.更多还原