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中红外光谱无创伤检测血糖新方法

A Novel Non-invasive Method of Blood Glucose MeasurementUsing FT-Mid-IR Spectroscopy

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【作者】 赵莹张元福杨丽敏徐怡庄翁诗甫杨展澜武惠忠周维金徐端夫吴瑾光

【Author】 ZHAO Ying~(1,2), ZHANG Yuan-Fu~1, YANG Li-Min~1, XU Yi-Zhuang~1, WENG Shi-Fu~1, YANG Zhan-Lan~1, WU Hui-Zhong~3, ZHOU Wei-Jin~1, XU Duan-Fu~2, WU Jin-Guang~(1*)(1. College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China; 2. State Key Laboratory of Polymer Physics and Chemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, China; 3. Beijing Rayleigh Analytical Instrument Corporation, Beijing 100015, China)

【机构】 北京大学化学与分子工程学院北京瑞利分析仪器公司中国科学院化学研究所高分子物理与化学国家重点实验室北京大学化学与分子工程学院 北京100871中国科学院化学研究所北京100080北京100871北京100015北京100871

【Abstract】 The blood glucose concentrations of volunteers from diabetes patients and healthy adults(all patients and volunteer who joined this experiment gave their consents) were measured by using a modified WQF-200 FTIR spectrometer with a newly designed ATR accessory. The results of this method are in good agreement with the clinical blood detection. The determination basis for this technique from the physiological point of view are also discussed based on the experimental results, which indicated that the glucose components measured by the FT-Mid-IR-ATR are from the secretions on the skin and glucose components within the body. The glucose components in both sources exhibit a linear relationship with blood glucose concentration within the body. All the results demonstrated that blood glucose concentration can be measured in a convenient, rapid and non-invasive way using ATR-FTIR spectroscopy, which is suitable for developing of a new technique to monitor the continuous variation of blood glucose concentration of diabetes patients in real time.

【关键词】 红外光谱血糖糖尿病
【Key words】 IR SpectroscopyBlood glucoseDiabetes
【基金】 国家自然科学基金(批准号:30371604,50203001);国家重大基础研究前期专项(批准号:2002CCA01900);教育部博士点基金(批准号:20030001069)资助.
  • 【文献出处】 高等学校化学学报 ,Chemical Research In Chinese Universities , 编辑部邮箱 ,2005年06期
  • 【分类号】R446.1
  • 【被引频次】26
  • 【下载频次】357
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