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以壳聚糖为载体的内毒素吸附剂

Adsorbents for Endotoxin Based on Chitosan Matrix

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【Author】 WANG Hui-Yan1, HOU Guang-Hui1, YU Mei1, YUAN Zhi~1* , LIU Bin2, ZHAO Cheng-Mei2(1. State Key Laboratory of Functional Polymer Materials for Adsorption and Separation, Institute of Polymer Chemistry, Nankai University, Tianjin 300071, China;2. Tianjin Medical College, Tianjin 300052, China)

【机构】吸附分离功能高分子材料国家重点实验室；南开大学高分子化学研究所；天津医学高等专科学校；天津医学高等专科学校天津300071；天津300071；天津300052；天津300052；

【Abstract】 The endotoxin adsorbents were prepared by coupling divinyl amine ligands on crosslinked chitosan matrix. Their adsorption ability to endotoxin was compared. It was found that the adsorbent with polyethylene polyamine ligand had the highest adsorption capacity and its clearance percent for endotoxin in endotoxemia plasma was over 80%. The results also showed that the adsorbent has good blood compatibility and clinical application foreground.更多还原

【关键词】壳聚糖；内毒素；吸附剂；血液灌流；
【Key words】 Chitosan； Endotoxin； Adsorbent； Hemoperfusion.；

【基金】国家“九七三”计划(批准号:G1999064707);国家自然科学基金(批准号:50373021);博士学科点基金(批准号:20030055038);南开大学科技创新基金资助.

【文献出处】高等学校化学学报 ,Chemical Research In Chinese Universities , 编辑部邮箱 ,2005年04期

【分类号】TQ424
【被引频次】30
【下载频次】374

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