【摘要】 用电化学和圆二色谱(CD)技术研究了5个1,4-二氢吡啶(1,4-DHP)衍生物与小牛胸腺DNA(CT-DNA)的相互作用.结果表明,1,4-DHP衍生物与CT-DNA相互作用是通过嵌入的方式进行的,相互作用的强弱与1,4-DHP衍生物的立体结构有关.1,4-DHP衍生物4-取代基空间位阻越小,嵌入到CT-DNA的程度越大.相反,空间位阻较大的1,4-DHP衍生物嵌入CT-DNA程度较小.非平面结构的1,4-DHP衍生物使CT-DNA双螺旋链结构松散程度增大.更多还原

【Abstract】 The interactions of five kinds of 1,4-dihydropyridine(1,4-DHP) derivatives with calf thymus DNA(CT-DNA) were investigated by the electrochemical method and circular dichroism(CD). The results indicated that the interaction between 1,4-DHP derivatives and CT-DNA was in the intercalative mode. The strength of the interaction increases with the decrease in the steric hindrance of 1,4-DHP derivatives. DNA double helix in solution become more loose in the presence of non-planar structure 1,4-DHP derivatives.更多还原