【摘要】 采用循环伏安法、线性扫描伏安法、微分脉冲伏安法、计时库仑法和恒电位库仑法详细研究了盐酸胺碘酮的电化学行为.结果表明,在微分脉冲伏安模式下,盐酸胺碘酮在pH 4.65的B-R缓冲液中,在+0.85 V(vs.Ag/AgCl)电位处产生一灵敏的阳极氧化峰,该峰电流值与盐酸胺碘酮的浓度在2.0×10-7~4.0×10-6mol/L范围内呈良好的线性关系,据此建立了微分脉冲伏安法检测盐酸胺碘酮的方法,其最低检测限为3.3×10-8mol/L,该法应用于兔子血清及尿样中盐酸胺碘酮的测定,回收率达到91.1%~94.0%.并详细讨论了盐酸胺碘酮在玻碳电极上的电化学反应机理.更多还原

【Abstract】 The electrochemical behavior of amiodarone on a glassy carbon electrode was investigated by cyclic voltammetry,linear sweep voltammetry,chronocoulometry and bulk electrolysis with coulometry.It was found that amiodarone would give a sensitive oxidation peak at +0.85V in the BR buffer solution（pH 4.65） under the differential pulse voltammetric（DPV） mode.The peak current was linear with the concentration of amiodarone in the range of 2.0×10^-7～4.0×10^-6 mol/L.Based on which,a DPV method for determination of amiodarone with the detection limit of 3.3×10^-8 mol/L has been developed.The proposed method has been used for determination of amiodarone in the rabbit serum and urine sample,the recovery was found to be in the range of 91.1%～94.0%.The mechanism for this electrochemical reaction at the glassy carbon electrode was also discussed in this paper.更多还原