节点文献
萘丙胺除草剂及其中间体的光学异构体分离研究
Separation of Optical Isomers of the Herbicide Naproanilide and Its Intermediate on Cellulose tris-(3,5-dimethylphenylcarbamate) and (S,S)-Whelk-O 1
【摘要】 萘丙胺为芳氧链烷酰胺类水田除草剂,α氯代丙酰替苯胺是合成萘丙胺类除草剂的重要中间体。萘丙胺具有旋光性,其中只有R异构体有除草活性。本实验在自制的纤维素三(3,5二甲苯基氨基甲酸酯)(CDMPC)和Pirkle型(S,S)WhelkO1手性固定相上,改变流动相正己烷中醇类添加剂的种类和浓度,对萘丙胺及其中间体α氯代丙酰替苯胺进行了对映体分离研究,并对它们的手性识别机理进行了初步的探讨。研究结果表明,萘丙胺及其中间体获得了很好的分离,最大分离度分别为2.42和2.15。
【Abstract】 Both the aryloxypropionic acid herbicide naproanilide and its intermediate α-chloro-propionanilide have two optical isomers. (S)-configuration of naproanilide has no biological activity. In this paper, the enantioseparation of naproanilide and its intermediate was studied using self-prepared cellulose tris-(3,5-dimethylphenylcarbamate)(CDMPC) and (S,S)-Whelk-O 1, by changing the type and concentration of alcohol modifier, and acetic acid modifier concentration in hexane mobile phase. And then their chiral recognition mechanism was discussed. The experiment results show that naproanilide and its intermediate can be separated completely, and the maximal resolution factor are 2.42, 2.15, respectively.
【Key words】 Naproanilide； α-chloro-propionanilide； enantioseparation； cellulose tris-(3； 5-dimethylphenylcarbamate)； chiral stationary phase；
- 【文献出处】 分析化学 ,Chinese Journal of Analytical Chemistry , 编辑部邮箱 ,2005年05期
- 【分类号】TQ457
- 【被引频次】10
- 【下载频次】126