【摘要】 用水解沉淀法合成了纳米Fe3O4粒子,并在其悬浮液中原位包覆聚苯胺,制备出纳米Fe3O4/聚苯胺复合粒子。研究了两种纳米粒子在交变磁场下的发热性能,对它们在定向集热治疗肿瘤中的应用前景进行了评价。纳米Fe3O4粒子的粒径为10~30 nm,表面包覆聚苯胺后,复合粒子的粒径为30~50 nm。纳米Fe3O4粒子的比饱和磁化强度为50.05 Am2/kg,矫顽力为10.9 kA/m;纳米Fe3O4/聚苯胺复合粒子的比饱和磁化强度为26.34 Am2/kg,矫顽力为0。在10 mg/mL的生理盐水悬浮液中,在外加交变磁场作用30 min后,纳米Fe3O4粒子悬浮液的温度为63.6℃,纳米Fe3O4/聚苯胺悬浮液的温度为52.4℃,二者均达到了医学上定向集热治疗肿瘤用热籽的发热要求,是很有应用前景的医用纳米材料。更多还原

【Abstract】 The Fe₃O₄/polyaniline composite nanoparticles with diameters of 30～50nm were prepared.The Fe₃O₄ nanoparticles with diameters of 10～30nm were encapsulated with polyaniline（PANI） by in-situ polymerization.The inductive heating property of Fe₃O₄ nanoparticles and Fe₃O₄/polyaniline composite nanoparticles in an alternating current magnetic field was investigated.The potential of the two kinds of nanoparticles was evaluated for the（localized） hyperthermia treatment of cancers.The saturation magnetization M_s and coercivity H_c of Fe₃O₄ nanoparticles（are 50.05emu/g） and 137 Oe respectively,the Fe₃O₄/polyaniline composite nanoparticles,26.34emu/g and 0 Oe.Exposed in the alternating current magnetic field for 30 min,the temperatures of physiological salt water suspension containing Fe₃O₄ nanoparticles or Fe₃O₄/polyaniline composite nanoparticles are 63.6℃ and 52.4℃ respectively.These two kinds of nanoparticles would be useful as good thermoseeds for the localized hyperthermia treatment of cancers.更多还原