【摘要】 目的:观察α-干扰素治疗前后慢性乙肝患者胆碱酯酶(CHE)活性及乙肝病毒DNA(HBV-DNA)含量的变化。方法:CHE活性采用酶动力学方法,HBV-DNA采用实时荧光PCR定量法。结果:经α-干扰素治疗后,32例患者HBV-DNA含量明显下降(P<0.01),24例HBV-DNA含量无明显变化(P>0.05);所有经α-干扰素治疗后的56例患者CHE明显升高(P<0.01),而未经α-干扰素治疗的39例慢性乙肝患者与正常对照一样CHE无明显变化(P>0.05),血清CHE的升高与α-干扰素的抗病毒效果无相关性。结论:CHE的动态监测可反映α-干扰素治疗过程慢性乙肝患者肝纤维化的改善程度。更多还原

【Abstract】 Objective To investigate the changes of serum cholinesterase (CEH) activity and HBV-DNA content in patients with chronic B hepatitis after α-interferon treatment. Methods Serum CHE activity (with bio-chemical method) and HBV-DNA content (with RT-PCR) were determined in 56 patients with chronic B hepatitis both before and after six months α-interferon treatment as well as in 39 patients with chronic B hepatitis without α-intenferon treatment and 51 controls. Results In all the 56 patients treated with α-interferon, the serum CHE activity readings were significantly higher than those before treatment (P<0.01). In the 39 patients without interferon treatment and 51 controls, the CHE activity readings changed little throughout the observation period. However only 32 of the 56 patients had their HBV-DNA contents dropped significantly (vs before treatment, P<0.01). Contents of HBV-DNA dropped very little in the remaining 24 patients (vs before treatment, P>0.05). The increase of CHE activity after α-interferon therapy was not correlated with the anti-viral efficacy. Conclusion As generally accepted, the degree of hepatic fibrosis in patients with chronic hepatitis was inversely proportional to the CHE activity. Dynamic monitoring of serum CHE activity during α-interferon treatment might indirectly reveal the improvement of the status of hepatic fibrosis.更多还原