【摘要】 目的:探讨糖尿病患者生长激素(GH)、糖化血红蛋白(GHbA1C)水平与糖尿病肾脏微血管病变的关系。方法:采用放射免疫分析(RIA)检测GH和β2-m;用层析法检测GHbA1C;用电极法测定空腹血糖(FBG)。结果:GH、GHbA1C、β2-m及FBG水平糖尿病控制组较差组>控制较好组>正常对照组,两两比较均为(P<0.01)。结论:GH水平的增高与糖尿病肾脏微血管病变密切相关,GH、GHbA1C、β2-m及FBG联检对糖尿病肾病的预防及诊断有重要意义。更多还原

【Abstract】 Objective To evaluate the relationship between blood levels of growth hormone, glycosylated hemoglobin and micro-vascular nephropathy in patients with diabetes. Methods Blood growth hormone and β₂-m levels were determined with RIA and GHbA 1C,blood glucose were determined with biochemical method in 41 diabetic patients and 32 controls. Results The blood levels of growth hormone, glycosylated hemoglobin, β₂-microglobin and fasting blood glucose in the patients with diabetes well controlled （n=22） were significantly higher than those in controls and levels in patients with diabeties poorly controlled （n=19） were again significantly higher than those in patients with diabetes well controlled （P<0.01）. Conclusion There was close relationship between blood growth hormone levels and degree of micro-vascular nephropathy in diabetic patients. Combined determination fo blood growth hormone, glycosylated hemoglobin, β₂-mciroglobin and fasting blood glucose is very important for early detection of diabetic nephropathy.更多还原