【摘要】 目的:观察急性胰腺炎病人尿Alb、IgG、β2-m变化情况,分析其发生的机理及临床意义。方法:采集急性胰腺炎患者的静脉血,使用放射免疫分析测定尿Alb、IgG、β2-m含量。血BUN、Cr使用自动生化仪检测。结果:急性胰腺炎时存在尿Alb、IgG、β2-m水平升高,急性胰腺炎早期BUN、Cr处于正常水平。结论:急性胰腺炎早期即可出现肾功能损害。尿Alb、IgG、β2-m三者不能用来区分急性胰腺炎的严重程度。更多还原

【Abstract】 Objective To investigate the cause and clinical significance of changes of urinary albumin, IgG and β₂-m contents in patients with acute pancreatitis. Methods Urinary contents of albumin IgG and β₂-m （with RIA） as well as serum levels of BUN, creatinine （with biochemical methods） were determined in 89 patients with acute pancreatitis （severe 12, mild 27） and 30 controls. Results Urinary concentrations of albumin,IgG and β₂-m were significantly higher in patients with acute pancreatitis （both mild and severe type） than those in controls （P<0.05）; however, the serum BUN and creatinine levels were about the same （P>0.05）. Differences between the urinary contents of these proteins in the two groups of acute pancreatitis patients （severe vs mild） were slight. Conclusion Damage of renal function as shown by increase of urinary concentrations of albumin,IgG and β₂-m could be demonstrated in patients with acute pancreatitis long before detection of any significant changes of serum BUN and creatinine levels, even in cases of mild pancreatitis.更多还原