【摘要】 基因沉默(genesilencing)是指生物体中特定基因由于种种原因不表达或者表达减少的现象。基因沉默发生在两种水平上,一种是由于DNA甲基化、异染色质化以及位置效应等引起的转录水平上的基因沉默;另一种是转录后基因沉默。RNA干扰(RNAi)是一种新发现的通过dsRNA介导的特异同源靶基因途径,RNAi的应用有望成为一种防治疾病的新方法。更多还原

【Abstract】 Gene silencing refers to the phenomena of specific gene un-expressing.There are two kinds of gene silencing including transcriptional gene silencing and post-transcriptional gene silencing.RNA interference (RNAi) is the process of post-transcriptional gene silencing by which double-stranded RNA (dsRNA) directs sequence-specific degradation of homologous mRNA.Scientists have carried out researches on the therapy for different diseases by RNAi technology and it will be a novel therapy for cancer and viral diseases.更多还原