【摘要】 【目的】探讨山东省围产儿出生缺陷的危险因素,为提高出生人口素质提供参考依据。【方法】采用以医院为基础的1:1配比的病例对照研究方法,以统一的调查表及调查方式对341例出生缺陷儿和对照的父母进行了调查,应用SAS软件对所有调查因素进行单因素及多因素非条件Logistic回归分析。【结果】出生缺陷的主要危险因素是:多次自然流产(OR=12.72)、有既往分娩畸胎儿史(OR=10.12)、妊娠异常反应史(OR=20.10)、母亲孕期饲养宠物(OR=25.14)、感冒并发烧>38℃(OR=20.90)、服用镇静药(OR=7.16)、解热镇痛药(OR=26.13)、激素类药(OR=11.31)、接触有机溶剂(OR=13.01)、母亲孕期有不良精神刺激(OR=12.08)、父亲接触噪声(OR=6.74)、父亲接触有机溶剂(OR=6.27)。【结论】母亲孕期饲养宠物、感冒并发烧>38℃、服用镇静药、解热镇痛药、激素类药、接触有机溶剂、母亲孕期有不良精神刺激、多次自然流产、母亲职业为工人、农民,有既往分娩畸胎儿史、妊娠异常反应史,父亲接触噪声、接触有机溶剂等是围产儿出生缺陷的危险因素。更多还原

【Abstract】 [Objective] To investigate the possible risk factors of perinatal birth defects in Shandong province. [Methods] A hospital-based case-control study was carried out on 341 cases of birth defects and 341 controls. The parents of cases and controls were interviewed with a uniformed questionnaire. Unconditional Logistic Regression model was used for univalent and multivariate analysis on SAS. [Results] The analysis of univalent and multivariate showed that main risk factors of perinatal birth defects as multiple spontaneous abortions(OR= 12.72), maternal history of birth defects(OR= 10.12), pregnancy complications(OR =20.10), raising pets (OR=25.14),with common cold accompanied fever above 38℃(OR=20.90), taking sedatives (OR=7.16), taking analgesiscs(OR=26.13), hormone drugs(OR=11.31) .exposure to organic solvents(OR=13.01) ,morthers’ bad moral irritate(OR=12.08) during pregnancy, fathers’ exposure to noise(OR=6.74),exposure to organic solvents (OR=6.27). [Conclusions] Some risk factors were identified as having important effect on perinatal birth defects, including multiple spontaneous abortions, mothers’ occupation being workers.or peasants,maternal history of fetus’s congenital malformation, pregnancy complications, raising an pets, with common cold accompanied fever above 38℃,taking sedatives.taking analgesiscs, hormone drugs,exposure to organic solvents, morthers’ bad moral irritate during pregnancy, fathers’ exposure to noise,exposure to organic solvents.更多还原