【摘要】 目的:评价头孢替唑钠治疗小儿急性细菌性下呼吸道感染的临床有效性、安全性。方法:轻、中度急性细菌性下呼吸道感染患儿115例分成2组,头孢替唑组58例,予头孢替唑钠20～80mg/(kg·d),溶于10%葡萄糖溶液中,分2次静脉滴注。头孢哌酮组57例,予头孢哌酮50～150mg/(kg·d),分二次静脉滴注。两组均以7~10d为一疗程。结果:头孢替唑钠组与头孢哌酮组的临床有效率分别为93%与91%(P>0.05),细菌清除率分别为92%与89%(P>0.05)。两组均无明显的不良反应。结论:头孢替唑可作为治疗小儿轻、中度急性细菌性下呼吸道感染有效和安全的抗生素。更多还原

【Abstract】 Objective: To evaluate clinical efficacy and safety of ceftezole sodium in treating acute bacterial infections in lower respiratory tract in children. Methods: 115 children with mild or moderate acute bacterial infections in lower respiratory tract were randomly divided into two groups: 58 in ceftezole sodium group, treated with ceftezole in 10% GS at dosage of 10 ~ 40 mg/kg, iv., bid, 57 in cefoperazone group, treated with cefoperazone at dosage of 25 ~ 75 mg/kg, iv., bid. Both groups were treated for 7 ~ 10 days as a course of treatment. Result: The effective rates of ceftezole sodium group and cefoperazone group were 93% and 91% (P > 0.05), respectively, and the bacterial clearance rates were 92% and 89% (P > 0.05), respectively. No visible adverse drug reaction was detected in both groups. Conclusion: Ceftezole sodium can be used as an effective and safe agent in treating children with mild or moderate acute bacterial infections in lower respiratory tract.更多还原