【摘要】 目的探讨鼻咽癌组织中HSP70、Ki-67和nm23-H1蛋白表达的临床价值。方法采用免疫组织化学二步法,检测50例鼻咽癌患者鼻咽部或颈淋巴结组织中HSP70、Ki-67和nm23-H1蛋白表达水平。结果50例鼻咽癌组织中HSP70、Ki-67和nm23-H1阳性表达率分别为36.0%(18/50)、98.0%(49/50)和50.0%(25/50);HSP70和nm23-H1蛋白在Ⅱ-Ⅲ期和Ⅳa期中阳性表达率均有显著性差异(P=0.016,P=0.037);Binarylogistic回归模型分析HSP70、nm23-H1表达是鼻咽癌局部复发或远处转移的相关因素(P=0.022,P=0.038);Cox多因素回归模型分析HSP70表达是影响患者生存期的独立因素(P=0.001);nm23-H1与HSP70表达呈负相关(P=0.003);Ki-67表达与鼻咽癌局部复发或远处转移及生存期均无相关性。结论检测鼻咽癌组织中HSP70和nm23-H1表达对指导治疗及评价预后有重要的临床意义。更多还原

【Abstract】 OBJECTIVE To explore the clinical valueof expression of HSP70, Ki-67 and nm23-H1 in nasopha-ryngeal carcinoma (NPC). METHODS Expression ofHSP70,Ki-67 and nm23-H1 were examined in primarytumor tissues or metastasis cervical lymph nodes of50 patients with NPC by immunohistochemicaltechniques. RESULTS The positive rates of HSP70,Ki-67 and nm23-H1 in 50 patients were 36.0 %(18/50),98.0 %(49/50) and 50.0 %(25/50) respectively. The posi-tive expression of HSP70 , nm23-H1 in Ⅱ -Ⅲ stageswere significantly different from that of Ⅳ a stage (P=0.016,P = 0.037). Expression of HSP70, nm23-H1were the factor of regional recurrence or distantmetastases in Binary logistic regression analysis (P=0.022,P =0.038). COX multivariate analysis identi-fied that expression of HSP70 was independent factorto overall survival (P =0.001); Expression of nm23-H1 protein had negative correlation with HSP70(P=0.003). Expression of Ki-67 had no correlation withregional recurrence or distant metastasis and overallsurvival. CONCLUSION The detection of HSP70,nm23-H1 expressions is valuable to the estimation ofprognosis and treatment of NPC.更多还原