【摘要】 目的观察长期低剂量红霉素治疗慢性鼻窦炎的疗效。方法自2002年5月-2002年10月,对68例慢性鼻窦炎患者应用低剂量红霉素治疗,3个月、6个月后分别观察其症状、鼻内镜检查、鼻窦CT检查及鼻窦黏膜病理的改善情况,同时检测治疗前后的糖精传输时间(saccharinetime,ST)。结果3个月、6个月后各项症状及检查好转率分别为:63.2%、69.1%鼻腔通气改善;58.8%、64.7%鼻涕量减少;70.3%、75.7%头痛减轻;23.8%、23.8%嗅觉改善;52.8%、62.3%鼻内镜检查好转;50.8%、55.9%CT扫描较用药前改善:46.7%、53.3%病理检查示鼻窦黏膜炎症减轻。平均ST治疗前为35.6±6.5分钟,用药3个月后为28.3±6.4分钟,6个月后为18.9±7.6分钟。结论长期低剂量应用红霉素对治疗慢性鼻窦炎有较好的疗效。更多还原

【Abstract】 OBJECTIVE To study the curative effect of long-term low-dose erythromycin treatment of chronic sinusitis. METHODS Sixty eight patients with chronic sinusitis were treated with low-dose erythromycin from May 2002 to October 2002. They were assessed about their symptoms, nasal endoscopic examination, CT scan of nasal sinuses and the pathology of sinus’s mucosa after 3 and 6 months. Saccharine transit time (ST) was measured to assess the transporting function of nasal mucosa before and after treatment. RESULTS Improvements were seen in stuffy nose, runny nose, headache, sense of smell, nasal endoscopic examination, CT scan and pathology after 3 and 6 months. The effective rates of stuffy nose, runny nose, headache, sense of smell, nasal endoscopic examination, CT scan and pathology at 3 and 6 months were 63.2 % and 69.1 %, 58.8 % and 64.7%, 70.3 % and 75.7 %, 23.8 % and 23.8 %, 52.8 % and 62.3 %, 50.8 % and 55.9 %, 46.7 % and 53.3 % respectively. The mean ST were 35.6 ± 6.5 minutes before treatment. The mean ST were 28.3 ± 6.4 minutes and 18.9 ± 7.6 minutes after patients had took medicines at 3 and 6 months. CONCLUSION There was a significant effect of long-term low-does erythromycin treatment on chronic sinusitis patients.更多还原