【摘要】 目的探讨成人缓发性自身免疫性糖尿病(LADA)临床特征及与2型糖尿病患者的差异。方法对40例缓发性自身免疫性糖尿病、30例1型糖尿病、128例2型糖尿病及100例健康对照者进行身高、体重、血糖、糖化血红蛋白、胰岛素、C肽、血脂、血尿酸等水平检测。结果LADA患者体重指数、糖化血红蛋白、空腹血糖、C肽、餐后血糖、刺激后C肽、胰高血糖素、总胆固醇、高密度胆固醇、低密度胆固醇、甘油三酯及血尿酸水平分别为(21.73±3.96)kg/m2、(8.72±1.92)%、(16.87±6.70)mmol/L、(23.79±8.77)mmol/L、(0.50±0.30)nmol/L、(0.90±0.50)nmol/L、(84.12±7.31)pg/dl、(4.79±0.98)mmol/L、(1.08±0.53)mmol/L、(3.37±1.03)mmol/L、(1.89±1.03)mmol/L及(269.48±76.11)μmol/L,多数指标介于T1DM与T2DM水平之间。结论在表型方面LADA患者明显有别于T2DM患者。更多还原

【Abstract】 Objective To discribe the characteristics in clinical and biochemical aspects.of latent autoimmune diabetes of adults (LADA). Methods A total of 298 subjects consisted of 40 LADA,30 type 1 diabetes (T1DM),128 type 2 diabets (T2DM) (according to WHO 1999 diagnostic criteria, except subjects with the positivity of antibodies) respectively,and of 100 nondiabetic subjects as control group.Body mass index (BMI,kg/m 2) was calculated by formula and serum glucose (BG),lycosylated hemoglobin (HbAlc),C-peptide (C-P),lipid and blood uric acid (UA) levels were tested.Results The levels of BMI,HbAlc,fasting blood glucose (FBG), fasting C-peptide (FC-P),postprandial blood glucose (PBG),postprandial C-peptide(PC-P), glucagons (GN),total cholesterol (TCh),high density cholesterol (HDL-C),low density cholesterol (LDL-C),triglyceride (TG) and UA in subjects with LADA were (21.73±3.96)kg/m 2,(8.72±1.92)%,(16.87±6.70)mmol/L,(23.79±8.77)mmol/L,(0.50±0.30)nmol/L,(0.90±0.50)nmol/L,(84.12±7.31)pg/dl,(4.79±0.98)mmol/L,(1.08±0.53)mmol/L,(3.37±1.03)mmol/L,(1.89±1.03)mmol/L and(269.48±76.11)μmol/L respectively. The values of above variables in paticents with LADA were between T1DM and T2DM group.Conclusion The feature of subject with LADA was deferent from subject with T2DM.更多还原