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基因芯片检测广东省汉族人群HLA-DQB1基因多态性
HLA-DQB1 gene polymorphisms in Guangdong province detected by genechip
【摘要】 目的调查研究了700名广东省汉族人群HLA-DQB1等位基因频率及多态性分布。方法采用深圳益生堂生物企业有限公司研制开发的“HLA-DQB1低分辨率基因分型芯片试剂盒”,应用PCR-SSP+SSO芯片检测技术,对700名广东省的中国人群进行基因分型。结果鉴定了10个HLA-DQB1等位基因。广东省人群HLA-DQB1等位基因频率分布为HLA-DQB1*05>*0301>*0303>*0601>*02>*0302>*04>*0602>*0604>*0603。结论为我国疾病相关性研究、人类学研究提供了可靠的遗传学参数。
【Abstract】 Objective To explore HLA-DQB1 gene frequency(GF) in Southern China inhabitants.Methods DNA Microarray Kit for HLA-DQB1 LowRes Genotyping were used to detect HLA-DQB1 gene polymorphisms of 700 inhabitants in Southern China.Results Ten alleles of HLA-DQB1 were inspected and a series of gene frequency(GF) distribution was obtained as following: HLA-DQB1*05>*0301>*0303>*0601>*02>*0302>*04>*0602>*0604>*0603.Conclusion The GF data of Chinese in Southern China are useful to correlation of diseases and anthropologic research.
【Key words】 genechip； HLA-DQB1； gene polymorphisms； Southern China；
- 【文献出处】 第三军医大学学报 ,Acta Academiae Medicinae Militaris Tertiae , 编辑部邮箱 ,2005年22期
- 【分类号】Q987;
- 【被引频次】3
- 【下载频次】86