【摘要】 目的合成7-碱性侧链取代的异黄酮衍生物,对其亲/抗子宫活性进行初步评价。方法以间苯二酚和取代苯乙酸为原料,经多步反应合成异黄酮衍生物。对所得化合物用雌性小鼠动物模型分别测定了在1·1×10-2、1·85×10-3μmol/ml剂量时的亲/抗子宫活性。结果合成了22个化合物,其中4个中间体和12个目标物为新化合物。结论所测目标化合物均具有较弱的亲子宫活性;除化合物6a外,其余化合物均有较强的抗子宫活性。更多还原

【Abstract】 Objective To synthesize soybean isoflavones, and their 7-alkaline analogues and to evaluate their uterotrophic activities and anti-uterotrophic activities preliminarily. Methods The target molecules were synthesized by multi-step from resorcinol and p-substituted phenylacetic acid as the starting material. Their uterotrophic activities and anti-uterotrophic activities were evaluated by female mouse at the concentration of 1.1×10 -2 μmol/ml and 1.85×10 -3 μmol/ml. Results Twenty-two compounds were synthesized, among which 4 intermediates and 12 isoflavones are new compounds. Conclusion All the target molecules except for 6a show weak uterotrophic activities and high anti-uterotrophic activities.更多还原