【摘要】 目的:观察Cypher雷帕霉素药物洗脱支架在急性ST段抬高心肌梗死（ASTEMI）中的临床研究.方法:入选2003年10月至2005年6月确诊ASTEMI患者76例行急诊冠脉造影和PCI,冠脉造影后明确病变,然后行PTCA及支架置人.在PCI过程中置入Cypher西罗莫司药物洗脱支架.观察术中、住院、出院后有无严重心脏不良事件（包括死亡、非致命急性心肌梗死、靶病变靶血管重建率、再次入院）.结果:所有患者均经桡动脉行介入治疗,冠脉造影和支架的成功率为100%.共置人Cypher支架86枚,置人1个支架的患者为66例,置入2个支架的为10例.在支架长度中,支架₂8mm的有38枚支架,<28mm的有48枚支架.在支架直径中,支架₃.0mm的有76枚支架,<3.0mm的有10个支架.放入支架后梗死相关血管前向血流达TIMI3级的有69例,发生无复流的有3例,它们在术中、术后均应用Tirofiban.3例患者（3.9%）在住院期间发生不良事件.1个月随访发现1例三支血管病变患者在出院后1周猝死.出院后4～6个月以上随访有4例患者出现心绞痛入院行冠脉造影.其余患者无不适症状等.共有11例患者（14.4%）在支架术后4～7个月复查冠脉造影,再狭窄率为0%.4例出现心绞痛患者造影发现其它血管狭窄（既往存在）而行支架.结论:Cypher雷帕霉素药物洗脱支架在ASTEMI中的应用是安全和有效的,明显减少再狭窄率.更多还原

【Abstract】 Objective: To investigate the clinical study of cypher drug-eluting stent in patients with acute ST- segment elevation myocardial infarction. Methods: 76 patients with STEMI were included from Oct 2003 to June 2005. They were received emergency angiography and cypher drug-eluting stent within 12 hours from the beginning of the heart attack. The MACE were investigated during hospitalization and discharge.Results: Radial puncture was successful in all patients. The success rate for CAG and PCI were 100% , respectively. 86 stents were planted. TIMI3 in IRA reached in 69 patients after stent. Noreflow occurred in 3 patients who received tirofiban. 3 MACE were found during hospitalization. 1 patient died in one week later. Follow-up angiography was performed in 11 patients(14.4% ) . Patients treated with Cypher stents had a lower angiographic restenosis rate which was 0. Conclusion: Implanting of cypher drug-eluting stent was safe and feasible in patients with acute ST-segment elevation myocardial infarction. It can decreased the restenosis.更多还原